Reply to: Deep brain stimulation in Parkinson's disease can mimic the 300 Hz subthalamic rhythm Subthalamic high-frequency stimulation drives subthalamic oscillatory activity at stimulation frequency while firing rate is reduced
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چکیده
منابع مشابه
Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations.
High frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapeutic approach for the treatment of late-stage Parkinson's disease. Although the underlying cause of this illness remains a mystery, changes in firing rate and synchronized activity in different basal ganglia nuclei have been related to its symptoms. Here we investigated the impact of STN-HFS on firing...
متن کامل[High frequency stimulation of the subthalamic nucleus in Parkinson's disease].
has been a part of the CNRS unit of Professor Bernard Bioulac in Bordeaux since 2001, prior to which he was 'Chargé de Recherche' (CR1). For his PhD, which he obtained in 1993 in the field of neuroscience and pharmacology, Dr Benazzouz investigated a new therapeutical approach with high-frequency stimulation (HFS) of the subthalamic nucleus in a non-human primate model of Parkinson's disease (P...
متن کاملActivation of Subthalamic Neurons by Contralateral Subthalamic Deep Brain Stimulation
1 Title 1 2 Activation of Subthalamic Neurons by Contralateral Subthalamic Deep Brain Stimulation 3 in Parkinson Disease 4 5 6 Authors 7 8 Harrison C. Walker*, M.D., Ray L. Watts, M.D., Christian J. Schrandt, He Huang, 9 Stephanie L. Guthrie, C.R.N.P., Barton L. Guthrie, M.D., and Erwin B. Montgomery, Jr. 10 M.D. 11 12 13 Affiliations 14 15 1 Division of Movement Disorders, Department of Neurol...
متن کاملDual effect of high-frequency stimulation on subthalamic neuron activity.
Although it is well known that high-frequency stimulation (HFS) of the subthalamic nucleus (STN) alleviates the cardinal symptoms of Parkinson's disease, the underlying mechanisms are not fully understood. We investigated the effect of stimulation from low to high frequencies on rat STN neurons in naive and dopamine-depleted slices using whole-cell, current-clamp techniques and on-line artifact...
متن کاملSubthalamic deep brain stimulation at individualized frequencies for Parkinson disease.
OBJECTIVES The oscillation model of Parkinson disease (PD) states that, in the subthalamic nucleus (STN), increased θ (4-10 Hz) and β (11-30 Hz) frequencies were associated with worsening whereas γ frequencies (31-100 Hz) were associated with improvement of motor symptoms. However, the peak STN frequency in each band varied widely from subject to subject. We hypothesized that STN deep brain sti...
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ژورنال
عنوان ژورنال: Brain
سال: 2006
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awl210